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Vasilevsky, Sergey; Krivenko, Ol’ga; Sorokina, Irina; Baev, Dmitry; Tolstikova, Tatyana; Alabugin, Igor (, Molecules)The interaction of acetamidine and phenylamidine with peri-R-ethynyl-9,10-anthraquinones in refluxing n-butanol leads to the formation of cascade transformations products: addition/elimination/cyclization―2-R-7H-dibenzo[de,h]quinolin-7-ones and(or) 2-R-3-aroyl-7H-dibenzo[de,h]quinolin-7-ones. The anti-inflammatory and antitumor properties of the new 2-R-7H-dibenzo[de,h]quinolin-7-ones were investigated in vivo, in vitro, and in silico. The synthesized compounds exhibit high anti-inflammatory activity at dose 20 mg/kg (intraperitoneal injection) in the models of exudative (histamine-induced) and immunogenic (concanavalin A-induced) inflammation. Molecular docking data demonstrate that quinolinones can potentially intercalate into DNA similarly to the antitumor drug doxorubicin.more » « less
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Liu, Mingchen; Gray, Robert M.; Roy, Arkadev; Ingold, Kirk A.; Sorokin, Evgeni; Sorokina, Irina; Schunemann, Peter G.; Marandi, Alireza (, Conference on Lasers and Electro-Optics)
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Liu, Mingchen; Gray, Robert M.; Roy, Arkadev; Ingold, Kirk A.; Sorokin, Evgeni; Sorokina, Irina; Schunemann, Peter G.; Marandi, Alireza (, Conference on Lasers and Electro-Optics)null (Ed.)
